RNF19A 抗体 (AA 621-720) (AbBy Fluor® 647)
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- 抗原 See all RNF19A 抗体
- RNF19A (Ring Finger Protein 19A (RNF19A))
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抗原表位
- AA 621-720
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNF19A antibody is conjugated to AbBy Fluor® 647
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human DORFIN/RNF19
- 亚型
- IgG
- Top Product
- Discover our top product RNF19A Primary Antibody
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anti-Ring Finger Protein 19A (RNF19A) (N-Term) antibody
RNF19A 适用: 人, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 19A (RNF19A) (AA 741-825) antibodyRNF19A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 19A (RNF19A) (AA 739-837) antibodyRNF19A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E4 unconjugated
anti-Ring Finger Protein 19A (RNF19A) (AA 108-157) antibodyRNF19A 适用: 人, 小鼠, 犬, Cow, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 19A (RNF19A) (AA 384-413) antibodyRNF19A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- RNF19A (Ring Finger Protein 19A (RNF19A))
- 别名
- DORFIN/RNF19 (RNF19A 产品)
- 别名
- RNF19 antibody, RNF19A antibody, AA032313 antibody, Dorfin antibody, Rnf19 antibody, UIP117 antibody, Ubce7ip2 antibody, XYbp antibody, ring finger protein 19A, RBR E3 ubiquitin protein ligase antibody, ring finger protein 19A antibody, RNF19A antibody, Rnf19a antibody
- 背景
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Synonyms: Dorfin, Double ring finger protein, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, p38, p38 protein, Ring finger protein 19, RING finger protein 19A, Ring IBR ring domain containing protein Dorfin, RN19A_HUMAN, RNF19, RNF19A, Ubce7ip2, UIP117, XYbp, AA032313, DKFZP566B1346.
Background: Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson?s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.
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