Tubby Protein Homolog 1 (Tub-1) (AA 241-305) 抗体 (Biotin)
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- 抗原 See all Tubby Protein Homolog 1 (Tub-1) 抗体
- Tubby Protein Homolog 1 (Tub-1)
- 抗原表位
- AA 241-305
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- Human,Mouse,Rat,Cow,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TUB 1
- 亚型
- IgG
- Top Product
- Discover our top product Tub-1 Primary Antibody
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- Tubby Protein Homolog 1 (Tub-1)
- 别名
- TUB 1 (Tub-1 产品)
- 别名
- Tubby protein homolog 1 antibody, tub-1 antibody
- 背景
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Synonyms: F10B5.4, rd5, TUB 1, TUB, TUB_HUMAN, Tubby homologue, Tubby protein homolog 1, Tubby protein homolog.
Background: In contrast to the rapid early-onset weight gain seen in ob/ob mice (1-3), mutations in the tub gene lead to obesity gradually and strongly resemble late-onset obesity as seen in the human population (4). In addition to excessive deposition of adipose tissue, mice with the tub phenotype also suffer retinal degeneration and neurosensory hearing loss (4-6). The tripartite character of tubby phenotype is strikingly similar to human obesity syndromes such as Alstr (5) and Bardet-Biedl (6). A candidate for the tub gene has been described (4). A G_ transversion in this candidate gene eliminates a donor splice site in the 3' coding region resulting in a larger transcript containing an unspliced intron (4). A second prematurely truncated mRNA transcript with the unspliced intron was found to be expressed in the brains of tubby mice at a 2-3 fold higher rate as compared to B6 mice (4). It has been postulated that the phenotypic features of tubby mice can be attributed to cellular apoptosis triggered by the expression of a mutated tub gene (4).
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