GAN 抗体 (AA 351-450) (AbBy Fluor® 350)
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- 抗原 See all GAN 抗体
- GAN (Gigaxonin (GAN))
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抗原表位
- AA 351-450
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GAN antibody is conjugated to AbBy Fluor® 350
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应用范围
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Cow,Sheep,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Gigaxonin
- 亚型
- IgG
- Top Product
- Discover our top product GAN Primary Antibody
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anti-Gigaxonin (GAN) (AA 534-597) antibody
GAN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G7 unconjugated
anti-Gigaxonin (GAN) (AA 1-240) antibodyGAN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gigaxonin (GAN) (AA 534-597) antibodyGAN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Gigaxonin (GAN) (AA 351-450) antibodyGAN 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Gigaxonin (GAN) (AA 503-552) antibodyGAN 适用: 人, 大鼠, 小鼠, Cow, 兔, 犬, 马, 豚鼠, 小鸡, 猴, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Gigaxonin (GAN) (AA 30-326) antibodyGAN 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- GAN (Gigaxonin (GAN))
- 别名
- Gigaxonin (GAN 产品)
- 别名
- MGC81691 antibody, GAN antibody, A330045G18 antibody, gigaxonin antibody, GAN1 antibody, KLHL16 antibody, gigaxonin L homeolog antibody, gigaxonin antibody, giant axonal neuropathy antibody, gan.L antibody, gan antibody, GAN antibody, Gan antibody
- 背景
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Synonyms: FLJ38059, GAN, GAN1, Kelch-like protein 16, giant axonal neuropathy, KLHL16, GAN_HUMAN.
Background: Gigaxonin, also refered to as giant axonal neuropathy, GAN1, or KLHL16, controls protein degradation and is essential for neuronal function and survival. Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, playing a large role in neurofilament architecture. The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), and tags it for degredation. Overexpression of MAP1B may lead to neuronal cell death, whereas a reduction of MAP1B significantly improves the survival rate of neurons. Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, including accumulated intermediate filaments.
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