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AAV VP1 抗体 (AbBy Fluor® 647)

AAV VP1 适用: Adeno-Associated Virus (AAV) IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 647
产品编号 ABIN1388676
发货至: 中国
  • 抗原 See all AAV VP1 products
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    适用
    Adeno-Associated Virus (AAV)
    宿主
    • 13
    克隆类型
    • 13
    多克隆
    标记
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AAV VP1 antibody is conjugated to AbBy Fluor® 647
    应用范围
    • 11
    • 11
    • 3
    • 3
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    特异性
    This antibody will recognize many AAV strains, including AAV5, AAV4, AAV3B, AAV9, and AAV13
    交叉反应
    Virus
    交叉反应 (详细)
    AAV5
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1
    亚型
    IgG
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    别名
    Adeno-Associated Virus Capsid Protein VP1 (AAV VP1 产品)
    物质类
    Viral Protein
    背景

    Synonyms: capsid protein Adeno-associated 5 virus, capsid protein [Adeno-associated virus - 5], capsid protein AAV5, Parvovirus coat protein VP1, capsid protein.

    Background: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus

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