DOCK3 抗体 (AA 1001-1100)
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- 抗原 See all DOCK3 抗体
- DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))
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抗原表位
- AA 1001-1100
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DOCK3 antibody is un-conjugated
- 应用范围
- ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- Human,Mouse,Rat,Dog,Pig,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human DOCK3
- 亚型
- IgG
- Top Product
- Discover our top product DOCK3 Primary Antibody
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anti-Dedicator of Cytokinesis 3 (DOCK3) (AA 1630-1934) antibody
DOCK3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))
- 别名
- DOCK3 (DOCK3 产品)
- 别名
- MOCA antibody, PBP antibody, mKIAA0299 antibody, dedicator of cytokinesis 3 antibody, similar to dedicator of cytokinesis 3 antibody, dedicator of cytokinesis protein 3 antibody, dedicator of cyto-kinesis 3 antibody, DOCK3 antibody, LOC561387 antibody, dock3 antibody, LOC100474164 antibody, Dock3 antibody
- 背景
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Synonyms: Dedicator of cytokinesis protein 3, DOCK 3, MOCA, Modier of cell adhesion, Presenilin binding protein, DOCK3_HUMAN.
Background: MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.
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