ZWILCH 抗体
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- 抗原 See all ZWILCH 抗体
- ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZWILCH antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human ZWILCH
- 亚型
- IgG
- Top Product
- Discover our top product ZWILCH Primary Antibody
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anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 1-477) antibody
ZWILCH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) antibodyZWILCH 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 1-477) antibodyZWILCH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C10 unconjugated
anti-Zwilch, Kinetochore Associated, Homolog (ZWILCH) (AA 482-508), (C-Term) antibodyZWILCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB38573 unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))
- 别名
- ZWILCH (ZWILCH 产品)
- 别名
- CG18639 antibody, CG18729 antibody, Dmel\\CG18729 antibody, Zwilch antibody, hzwilch antibody, kntc1ap antibody, KNTC1AP antibody, hZwilch antibody, 2310031L18Rik antibody, si:ch211-242m18.4 antibody, wu:fb10f09 antibody, zwilch kinetochore protein antibody, CG18729 gene product from transcript CG18729-RA antibody, protein zwilch homolog antibody, Zwilch antibody, zwilch antibody, LOC100374963 antibody, ZWILCH antibody
- 背景
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Synonyms: hZwilch, KNTC1AP, MGC111034, Protein zwilch homolog, ZWILC_HUMAN, zwilch,y ZWILCH protein, Zwilch, kinetochore associated, homolog.
Background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.
- 基因ID
- 55055
- UniProt
- Q9H900
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