Akirin 1 抗体
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- 抗原 See all Akirin 1 (AKIRIN1) products
- Akirin 1 (AKIRIN1)
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Akirin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human AKIRIN1
- 亚型
- IgG
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anti-Akirin 1 (AKIRIN1) (N-Term) antibody
AKIRIN1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- Akirin 1 (AKIRIN1)
- 别名
- AKIRIN1 (AKIRIN1 产品)
- 别名
- C1orf108 antibody, RP11-781D11.2 antibody, STRF2 antibody, 6330407G11Rik antibody, wu:fa96c11 antibody, wu:fc08a11 antibody, zgc:64050 antibody, AKIRIN1 antibody, strf2 antibody, akirin 1 antibody, akirin 1 S homeolog antibody, akirin-1 pseudogene antibody, AKIRIN1 antibody, Akirin1 antibody, akirin1 antibody, akirin1.S antibody, LOC100316864 antibody, LOC100356339 antibody
- 背景
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Synonyms: AKIRIN 1, C1orf108, FLJ12666, OTTHUMP00000008669, RP11-781D11.2, STRF2, AKIR1_HUMAN.
Background: AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.
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