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Caspase 1 p20 抗体 (AA 188-290)

适用: 人 FACS, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386773
发货至: 中国
  • 抗原 See all Caspase 1 p20 products
    Caspase 1 p20
    抗原表位
    • 16
    • 16
    • 15
    • 1
    • 1
    AA 188-290
    适用
    • 50
    • 34
    • 32
    宿主
    • 48
    • 4
    克隆类型
    • 48
    • 4
    多克隆
    标记
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Caspase 1 p20 antibody is un-conjugated
    应用范围
    • 41
    • 37
    • 26
    • 26
    • 9
    • 8
    • 6
    • 2
    • 2
    • 2
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Caspase-1 p20
    亚型
    IgG
  • 应用备注
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Zhang, Liu, Sui, Cai, Liu, Zhu, Yin: "Cortistatin inhibits NLRP3 inflammasome activation of cardiac fibroblasts during sepsis." in: Journal of cardiac failure, (2015) (PubMed).

  • 抗原
    Caspase 1 p20
    别名
    Caspase-1 P20 (Caspase 1 p20 产品)
    背景

    Synonyms: caspase-1 isoform alpha p20 subunit,CASP 1, CASP1, Caspase 1 apoptosis related cysteine peptidase, Caspase 1 apoptosis related cysteine protease, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1B convertase, IL1BC, IL1BCE, Interleukin 1 beta convertase, Interleukin 1 beta convertase precursor, Interleukin 1 beta converting enzyme.CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20.

    Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

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