SIM2 抗体 (AA 321-430)
-
- 抗原 See all SIM2 抗体
- SIM2 (Single-Minded Homolog 2 (SIM2))
-
抗原表位
- AA 321-430
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This SIM2 antibody is un-conjugated
-
应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SIM2
- 亚型
- IgG
- Top Product
- Discover our top product SIM2 Primary Antibody
-
anti-Single-Minded Homolog 2 (SIM2) (AA 426-525) antibody
SIM2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) (AA 426-526) antibodySIM2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3E6 unconjugated
anti-Single-Minded Homolog 2 (SIM2) (N-Term) antibodySIM2 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) (AA 347-433) antibodySIM2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) antibodySIM2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) (N-Term) antibodySIM2 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼, 猴, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) (Internal Region) antibodyVerified SIM2 适用: 小鼠 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Single-Minded Homolog 2 (SIM2) (AA 342-525) antibodySIM2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
- 抗原
- SIM2 (Single-Minded Homolog 2 (SIM2))
- 别名
- SIM2 (SIM2 产品)
- 别名
- Xsim2 antibody, sim2-A antibody, xSim antibody, HMC13F06 antibody, HMC29C01 antibody, SIM antibody, bHLHe15 antibody, single-minded family bHLH transcription factor 2 S homeolog antibody, single-minded family bHLH transcription factor 2 antibody, single-minded homolog 2 (Drosophila) antibody, sim2.S antibody, sim2 antibody, SIM2 antibody, Sim2 antibody
- 背景
-
Synonyms: bHLHe15, Class E basic helix loop helix protein 15, Class E basic helix-loop-helix protein 15, MGC119447, SIM 2, SIM, Sim2, SIM2_HUMAN, Single minded homolog 2 Drosophila, Single minded homolog 2, Single-minded homolog 2, Transcription factor SIM2.
Background: The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome.
-
