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ARFGEF2 抗体 (AA 761-860)

ARFGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386203
发货至: 中国
  • 抗原 See all ARFGEF2 抗体
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    抗原表位
    • 14
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 761-860
    适用
    • 43
    • 19
    • 12
    宿主
    • 43
    克隆类型
    • 43
    多克隆
    标记
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARFGEF2 antibody is un-conjugated
    应用范围
    • 23
    • 12
    • 12
    • 11
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human ARFGEF2/BIG2
    亚型
    IgG
    Top Product
    Discover our top product ARFGEF2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    别名
    ARFGEF2/BIG2 (ARFGEF2 产品)
    别名
    AI463430 antibody, AW493672 antibody, BIG2 antibody, E230011G24Rik antibody, Big2 antibody, PVNH2 antibody, dJ1164I10.1 antibody, ADP ribosylation factor guanine nucleotide exchange factor 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) antibody, ARFGEF2 antibody, Arfgef2 antibody
    背景

    Synonyms: ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited, ADP ribosylation factor guanine nucleotide exchange factor 2, ARFGEF 2, ARFGEF2, ARFGEP2, BIG 2, BIG2, Brefeldin A inhibited 2, Brefeldin A inhibited GEP 2, Brefeldin A inhibited guanine nucleotide exchange protein 2, dJ1164I10.1, BIG2_HUMAN.

    Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

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