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RLIM 抗体 (AA 550-600)

RLIM 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1385938
发货至: 中国
  • 抗原 See all RLIM 抗体
    RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))
    抗原表位
    • 14
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 550-600
    适用
    • 38
    • 17
    • 17
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 33
    • 5
    克隆类型
    • 36
    • 2
    多克隆
    标记
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RLIM antibody is un-conjugated
    应用范围
    • 38
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human RNF12
    亚型
    IgG
    Top Product
    Discover our top product RLIM Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))
    别名
    RNF12 (RLIM 产品)
    别名
    NY-REN-43 antibody, RNF12 antibody, AL022832 antibody, AW743871 antibody, Ha1r antibody, Rnf12 antibody, R-LIM antibody, ring finger protein, LIM domain interacting antibody, XRnf12C protein antibody, RLIM antibody, Rlim antibody, xrnf12c antibody, rlim antibody
    背景

    Synonyms: RNF12, NY-REN-43, E3 ubiquitin-protein ligase RLIM, LIM domain-interacting RING finger protein, RING finger LIM domain-binding protein, R-LIM, RING finger protein 12, Renal carcinoma antigen NY-REN-43, RLIM

    Background: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

    基因ID
    51132
    UniProt
    Q9NVW2
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