MCPH1 抗体 (AA 11-110)
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- 抗原 See all MCPH1 抗体
- MCPH1 (Microcephalin 1 (MCPH1))
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抗原表位
- AA 11-110
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MCPH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠
- 预测反应
- Human,Dog
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
- 亚型
- IgG
- Top Product
- Discover our top product MCPH1 Primary Antibody
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anti-Microcephalin 1 (MCPH1) (AA 536-835) antibody
MCPH1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (N-Term) antibodyMCPH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) antibodyMCPH1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (AA 399-487) antibodyMCPH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Microcephalin 1 (MCPH1) (AA 399-487) antibodyMCPH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6F5 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- MCPH1 (Microcephalin 1 (MCPH1))
- 别名
- Microcephalin 1/BRIT1 (MCPH1 产品)
- 别名
- RGD1560642 antibody, MGC83773 antibody, MCPH1 antibody, mct antibody, brit1 antibody, MGC148665 antibody, BRIT1 antibody, MCT antibody, 5430437K10Rik antibody, D030046N04Rik antibody, microcephalin 1 antibody, microcephalin 1 S homeolog antibody, microcephaly, primary autosomal recessive 1 antibody, Mcph1 antibody, mcph1.S antibody, MCPH1 antibody, mcph1 antibody
- 背景
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Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.
Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.
- 途径
- Stem Cell Maintenance
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