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IL-6 抗体

Name: IL-6 抗体
Brand: antibodies-online
SKU: ABIN1383944
Availability: OutOfStock

IL6 适用: 人 ELISA, FACS, Func, ELISpot 宿主: 小鼠 Monoclonal B-E8 unconjugated

B-E8 with non-activated monocytes In the two cases, the dotted line represents the IgG1 isotype control (IL-6 抗体)

FACS

XG1 cell proliferation measurement with resazurin after 96 hours with IL-6 (1ng/ml) and different concentrations of antibody. (IL-6 抗体)

Func

Activated monocytes marked with B-E8 (IL-6 抗体)

FACS

3 images

(56 references)

产品编号 ABIN1383944

发货至: 中国

Datasheet as PDF

抗原 See all IL-6 (IL6) 抗体

IL-6 (IL6) (Interleukin 6 (IL6))
适用
181

124

71

25

21

21

14

12

7

6

4

3

3

3
人
宿主
197

85

50

14

4

3

2
小鼠
Compatible Secondaries
克隆类型
218

134

1
单克隆
标记
189

53

27

10

10

9

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1
This IL-6 antibody is un-conjugated
应用范围
265

131

103

52

47

46

41

41

37

30

25

25

20

18

15

8

7

7

6

5

5

3

2

2

1

1

1

1

1

1

1

1

1
ELISA, Flow Cytometry (FACS), Functional Studies (Func), ELISpot

特异性

Recognises both natural and recombinant human IL-6

纯化方法

Ion exchange chromatography

过滤

0.22 μm filtered

免疫原

Recombinant human IL-6,Myeloma X63/AG.8653 x Balb/c spleen cells

克隆位点

B-E8

亚型

IgG1 kappa

Biological Activity Comment

Inhibits IL-6 induced proliferation on XG1 Cell line

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anti-Interleukin 6 (IL6) (AA 26-50) antibody
IL6 适用: 人, 大鼠 ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interleukin 6 (IL6) (AA 110-185) antibody
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应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

缓冲液

Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

储存液

Without preservative

储存条件

4 °C

储存方法

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Sprynski, Hose, Caillot, Réme, Shaughnessy, Barlogie, Seckinger, Moreaux, Hundemer, Jourdan, Meissner, Jauch, Mahtouk, Kassambara, Bertsch, Rossi, Goldschmidt, Klein: "The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor." in: Blood, Vol. 113, Issue 19, pp. 4614-26, (2009) (PubMed).

Adam, Rabe, Suthaus, Grötzinger, Rose-John, Scheller: "Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor." in: Journal of virology, Vol. 83, Issue 10, pp. 5117-26, (2009) (PubMed).

Moreau, Garban, Attal, Michallet, Marit, Hulin, Benboubker, Doyen, Mohty, Yakoub-Agha, Leyvraz, Casassus, Avet-Loiseau, Garderet, Mathiot, Harousseau: "Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma." in: Blood, Vol. 112, Issue 9, pp. 3914-5, (2008) (PubMed).

Garban, Attal, Michallet, Hulin, Bourhis, Yakoub-Agha, Lamy, Marit, Maloisel, Berthou, Dib, Caillot, Deprijck, Ketterer, Harousseau, Sotto, Moreau: "Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma." in: Blood, Vol. 107, Issue 9, pp. 3474-80, (2006) (PubMed).

Moreau, Hullin, Garban, Yakoub-Agha, Benboubker, Attal, Marit, Fuzibet, Doyen, Voillat, Berthou, Ketterer, Casassus, Monconduit, Michallet, Najman, Sotto, Bataille, Harousseau: "Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol." in: Blood, Vol. 107, Issue 1, pp. 397-403, (2005) (PubMed).

Song, Torphy, Griswold, Shealy: "Coming of age: anti-cytokine therapies." in: Molecular interventions, Vol. 2, Issue 1, pp. 36-46, (2004) (PubMed).

Moreaux, Legouffe, Jourdan, Quittet, Rème, Lugagne, Moine, Rossi, Klein, Tarte: "BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone." in: Blood, Vol. 103, Issue 8, pp. 3148-57, (2004) (PubMed).

Derhaschnig, Bergmair, Marsik, Schlifke, Wijdenes, Jilma: "Effect of interleukin-6 blockade on tissue factor-induced coagulation in human endotoxemia." in: Critical care medicine, Vol. 32, Issue 5, pp. 1136-40, (2004) (PubMed).

Smith, Barg, Weedon, Papengelis, Smeets, Tak, Kraan, Coleman, Ahern: "Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints." in: Annals of the rheumatic diseases, Vol. 62, Issue 4, pp. 303-7, (2003) (PubMed).

Ancey, Menet, Corbi, Fredj, Garcia, Rücker-Martin, Bescond, Morel, Wijdenes, Lecron, Potreau: "Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation." in: Cardiovascular research, Vol. 59, Issue 1, pp. 78-85, (2003) (PubMed).

Choy: "Interleukin 6 receptor as a target for the treatment of rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 62 Suppl 2, pp. ii68-9, (2003) (PubMed).

Derenne, Monia, Dean, Taylor, Rapp, Harousseau, Bataille, Amiot: "Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells." in: Blood, Vol. 100, Issue 1, pp. 194-9, (2002) (PubMed).

Delneste, Charbonnier, Herbault, Magistrelli, Caron, Bonnefoy, Jeannin: "Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages." in: Blood, Vol. 101, Issue 1, pp. 143-50, (2002) (PubMed).

Leblond, Dhedin, Mamzer Bruneel, Choquet, Hermine, Porcher, Nguyen Quoc, Davi, Charlotte, Dorent, Barrou, Vernant, Raphael, Levy: "Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 3, pp. 772-8, (2001) (PubMed).

Jego, Bataille, Pellat-Deceunynck: "Interleukin-6 is a growth factor for nonmalignant human plasmablasts." in: Blood, Vol. 97, Issue 6, pp. 1817-22, (2001) (PubMed).

Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: "IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells." in: Cancer research, Vol. 61, Issue 7, pp. 3096-104, (2001) (PubMed).

Corbellino, Bestetti, Scalamogna, Calattini, Galazzi, Meroni, Manganaro, Fasan, Moroni, Galli, Parravicini: "Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy." in: Blood, Vol. 98, Issue 12, pp. 3473-5, (2001) (PubMed).

Haddad, Paczesny, Leblond, Seigneurin, Stern, Achkar, Bauwens, Delwail, Debray, Duvoux, Hubert, Hurault de Ligny, Wijdenes, Durandy, Fischer: "Treatment of B-lymphoproliferative disorder with a monoclonal anti-interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial." in: Blood, Vol. 97, Issue 6, pp. 1590-7, (2001) (PubMed).

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Foussat, Wijdenes, Bouchet, Gaidano, Neipel, Balabanian, Galanaud, Couderc, Emilie: "Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes." in: European cytokine network, Vol. 10, Issue 4, pp. 501-8, (2000) (PubMed).

show more references
抗原

IL-6 (IL6) (Interleukin 6 (IL6))

别名

IL-6 (IL6 产品)

别名

BSF2 antibody, HGF antibody, HSF antibody, IFNB2 antibody, IL-6 antibody, Il-6 antibody, ILg6 antibody, Ifnb2 antibody, il6 antibody, CHIL-6 antibody, interleukin 6 antibody, interleukin-6 antibody, IL6 antibody, Il6 antibody, il-6 antibody, IL-6 antibody

途径

TLR signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome