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CD22 抗体

CD22 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 2D6 unconjugated
产品编号 ABIN135158
发货至: 中国
  • 抗原 See all CD22 抗体
    CD22 (CD22 Molecule (CD22))
    适用
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    小鼠
    宿主
    • 86
    • 62
    • 14
    大鼠
    克隆类型
    • 109
    • 55
    单克隆
    标记
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    This CD22 antibody is un-conjugated
    应用范围
    • 98
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    Flow Cytometry (FACS)
    特异性
    Mouse CD22, Mr 150 kDa
    产品特性
    Rat Anti-Mouse CD22-UNLB
    纯化方法
    Purified
    免疫原
    Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
    克隆位点
    2D6
    亚型
    IgG1
    Top Product
    Discover our top product CD22 Primary Antibody
  • 应用备注
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Activ - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    样本量
    1 mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
    储存液
    Without preservative
    注意事项
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C
  • Kreimann, Jang, Rong, Greite, von Vietinghoff, Schmitt, Bräsen, Schiffer, Gerstenberg, Vijayan, Dittrich-Breiholz, Wang, Karsten, Gwinner, Haller, Immenschuh, Gueler: "Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation." in: Frontiers in immunology, Vol. 11, pp. 1204, (2020) (PubMed).

  • 抗原
    CD22 (CD22 Molecule (CD22))
    别名
    CD22 (CD22 产品)
    别名
    A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
    背景
    CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.
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