-
- 抗原 See all MLF1 抗体
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
-
抗原表位
- Thr78
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This MLF1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 犬, 绵羊, Chimpanzee
- 产品特性
- Concentration Definition: by UV absorbance at 280 nm
- 免疫原
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids surrounding of human MLF1IP protein.
- 亚型
- IgG
- Top Product
- Discover our top product MLF1 Primary Antibody
-
anti-Myeloid Leukemia Factor 1 (MLF1) antibody
MLF1 适用: 人 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A3 unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (pThr78) antibodyMLF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 215-244), (C-Term) antibodyMLF1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18643 unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 1-268) antibodyMLF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) antibodyMLF1 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 1-268) antibodyMLF1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 1-268) antibodyMLF1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 1-268) antibodyMLF1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) (AA 91-126) antibodyMLF1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51172 unconjugated
anti-Myeloid Leukemia Factor 1 (MLF1) antibodyMLF1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 65 kDa in size corresponding to MLF1IP protein by western blotting in the appropriate cell lysate or extract.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1.06 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
-
- 抗原
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
- 别名
- MLF1 (MLF1 产品)
- 别名
- MLF1 antibody, HLS7 antibody, myeloid leukemia factor 1 antibody, myeloid leukemia factor 1 L homeolog antibody, MLF1 antibody, mlf1.L antibody, mlf1 antibody, Mlf1 antibody
- 背景
-
This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Myeloid leukemia factor-1 (MLF1) Interacting Protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a novel polo-like kinase 1 (Plk1) substrate. Plk1 phosphorylation of MLF1IP induces ubiquitination and degradation of MLF1IP prior to the metaphase/anaphase transition. Several Plk1-dependent phosphorylation sites have been identified on MLF1IP by mass spectrometry. Mutations of these sites stabilize MLF1IP and inhibit mitotic progression. Subsequent in vitro and in vivo MLF1IP phosphorylation and stability assays have revealed that phosphorylation of Thr78 is critical for triggering Plk1-dependent MLF1IP degradation. Expression of a non-degradable Thr78Ala mutant was sufficient to induce a mitotic block. Timely phosphorylation of MLF1IP on Thr78 by Plk1 is critical for eliminating the MLF1IP-imposed mitotic block prior to anaphase onset. MLF1IP is speculated to be a novel tumor suppressor, whose function is required for proper sister-chromatid separation. Loss of MLF1IP function may result in improper segregation of chromosomes and genomic instability, thus promoting tumorigenesis.
Synonyms: FLJ23468 antibody, HHV8 LNAIP1 antibody, ICEN24 antibody, Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1 antibody - 基因ID
- 79682, 38016935
- UniProt
- Q71F23
-
You are here:
