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CBLC 抗体 (C-Term)

CBLC 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN129659
发货至: 中国
  • 抗原 See all CBLC 抗体
    CBLC (Cbl proto-oncogene C (CBLC))
    抗原表位
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    适用
    • 35
    • 2
    • 1
    宿主
    • 30
    • 5
    克隆类型
    • 30
    • 5
    多克隆
    标记
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    This CBLC antibody is un-conjugated
    应用范围
    • 34
    • 22
    • 17
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    原理
    Cbl-c Antibody
    交叉反应 (详细)
    This affinity purified antibody is directed against human Cbl-c protein.
    产品特性
    Synonyms: rabbit anti-Cbl-c Antibody, E3 ubiquitin-protein ligase CBL-C, RING finger protein 57, RING-type E3 ubiquitin transferase CBL-C, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C, CBLC, CBL3, RNF57
    纯化方法
    The product was affinity purified from monospecific antiserum by immunoaffinity purification.
    过滤
    Sterile filtered
    免疫原

    Immunogen: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-Terminal portion of Human Cbl-c.

    Immunogen Type: Conjugated Peptide

    亚型
    IgG
    Top Product
    Discover our top product CBLC Primary Antibody
  • 应用备注

    Immunohistochemistry Dilution: 1:500 - 1:3,000

    Application Note: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, immunoprecipitation and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~52 kDa in size corresponding to Cbl-c by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:500 - 1:3,000

    Immunoprecipitation Dilution: User Optimized

    ELISA Dilution: 1:10,000 - 1:50,000

    Other: User Optimized

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.42 mg/mL
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • 抗原
    CBLC (Cbl proto-oncogene C (CBLC))
    别名
    CBLC (CBLC 产品)
    背景
    Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57.  Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.  Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed).  Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.  Cbl-c knock out mice show no obvious phenotype.  Thus, the physiological role of Cbl-c is not known.
    基因ID
    23624, 125987803
    UniProt
    Q9ULV8
    途径
    EGFR Signaling Pathway
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