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NRF1 抗体 (AA 1)

NRF1 适用: 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN129526
发货至: 中国
  • 抗原 See all NRF1 抗体
    NRF1 (Nuclear Respiratory Factor 1 (NRF1))
    抗原表位
    • 15
    • 9
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1
    适用
    • 72
    • 42
    • 36
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 68
    • 5
    克隆类型
    • 60
    • 13
    多克隆
    标记
    • 36
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NRF1 antibody is un-conjugated
    应用范围
    • 60
    • 28
    • 14
    • 14
    • 12
    • 12
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a purified recombinant mouse NRF1 protein corresponding to - 534 of the Native
    Immunogentype:Recombinant
    亚型
    IgG
    Top Product
    Discover our top product NRF1 Primary Antibody
  • 应用备注
    This protein A purified antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 67 kDa in size corresponding to NRF1 by western blotting in the appropriate cell lysate or extract.  Splice variants exist for this protein that may result in the detection of lower molecular weight bands.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    2.3 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Hinkley, Morton, Ichinoseki-Sekine, Huertas, Smuder: "Exercise Training Prevents Doxorubicin-induced Mitochondrial Dysfunction of the Liver." in: Medicine and science in sports and exercise, Vol. 51, Issue 6, pp. 1106-1115, (2019) (PubMed).

    Miura, Saitoh, Kokubun, Owada, Yamauchi, Machii, Takeishi: "Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia." in: International journal of molecular sciences, Vol. 18, Issue 9, (2018) (PubMed).

    Joseph, Nguyen, Welter, Dominguez, Behnke, Adhihetty: "Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats." in: Biogerontology, Vol. 15, Issue 5, pp. 517-534, (2015) (PubMed).

  • 抗原
    NRF1 (Nuclear Respiratory Factor 1 (NRF1))
    别名
    NRF1 (NRF1 产品)
    别名
    ALPHA-PAL antibody, C87038 antibody, D6Ertd415e antibody, SC:BZ3C13.1 antibody, SC:bZ3C13.2 antibody, ube2h antibody, Nfe2l1_retired antibody, IBR/F antibody, NRF1 antibody, alpha-pal antibody, nrf-1 antibody, LOC100220087 antibody, nuclear respiratory factor 1 antibody, nuclear respiratory factor 1 S homeolog antibody, NRF1 antibody, Nrf1 antibody, nrf1 antibody, nrf1.S antibody
    背景
    NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.  NRF1 forms a homodimer and binds DNA as a dimer.  NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues.  Phosphorylation of NRF1 enhances DNA binding.  Multiple splice variants have been identified for this protein.
    Synonyms: alpha pal antibody, alpha palindromic binding protein antibody, locus control region factor 1 antibody, NFE2 related factor 1 antibody, nuclear respiratory factor 1 antibody, transcription factor 11 antibody
    基因ID
    18181, 13529317
    UniProt
    Q9WU00
    途径
    Regulation of Lipid Metabolism by PPARalpha
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