Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 20-30 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
HDAC3 is a member of the class I mammalian histone deacetylase family, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC3 is composed of 428 amino acid residues. HDAC3 interacts with a growing number of transcriptional factors including SMRT and N-CoR. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.Synonyms: HD3, Histone deacetylase 3, RPD3-2, SMAP45