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Caspase 8 抗体 (active, Cleavage Site)

Name: Caspase 8 抗体 (active, Cleavage Site)
SKU: ABIN127031
Availability: OutOfStock

CASP8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Image no. 1 for anti-Caspase 8 (CASP8) (active), (Cleavage Site) antibody (ABIN127031) (Caspase 8 抗体 (active, Cleavage Site))

1 image

产品编号 ABIN127031

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 8 (CASP8) 抗体

Caspase 8 (CASP8)
抗原表位
16

16

9

7

6

6

6

6

5

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
active, Cleavage Site
适用
132

67

60

22

16

16

10

1

1
人
宿主
126

23

5

2
兔
Compatible Secondaries
克隆类型
124

31
多克隆
标记
92

15

11

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This Caspase 8 antibody is un-conjugated
应用范围
138

48

43

38

27

26

24

18

17

17

7

4

4

4

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

The affinity purified antibody mainly detects the 26 kDa fully cleaved fragment and the 35-43 kDa intermediate of caspase-8 in apoptotic samples. Other species have not been tested.

纯化方法

Affinity chromatography

免疫原

Synthetic peptide surrounding the cleavage site of human Caspase-8

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应用备注

Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 10-20 mg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal

储存液

Thimerosal (Merthiolate)

注意事项

This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C/-80 °C

储存方法

Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
抗原

Caspase 8 (CASP8)

别名

Caspase-8 (CASP8 产品)

背景

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP-8, CASP8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MCH5, MORT1-associated CED-3 homolog

基因ID

841

NCBI登录号

NP_001073593

UniProt

Q14790

途径

Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades