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NCOA1 抗体 (pTyr416)

Name: NCOA1 抗体 (pTyr416)
SKU: ABIN126893
Availability: OutOfStock

NCOA1 适用: 人, 小鼠 WB, IF, EIA, FACS 宿主: 小鼠 Monoclonal 9A6 unconjugated

Western Blotting (WB) image for anti-Nuclear Receptor Coactivator 1 (NCOA1) (pTyr416) antibody (ABIN126893) (NCOA1 抗体 (pTyr416))

1 image

产品编号 ABIN126893

发货至: 中国

Datasheet as PDF

抗原 See all NCOA1 抗体

NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
抗原表位
15

5

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
pTyr416
适用
59

38

18

3

2

2

1

1

1
人, 小鼠
宿主
66

8
小鼠
Compatible Secondaries
克隆类型
57

17
单克隆
标记
41

5

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This NCOA1 antibody is un-conjugated
应用范围
52

16

13

13

11

8

6

4

3

3

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)

特异性

AM00145PU-N specifically interacts with activated src phosphorylated at Tyr 416 and with src family kinases phosphorylated at the corresponding Tyr in the activation loop. The antibody does not crossreact with the non-phosphorylated form of src nor with unrelated phosphorylation sites.

产品特性

Synonyms: c-Src, pp60c-src, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src

纯化方法

Subsequent Thiophilic Adsorption and Size Exclusion Chromatography.

免疫原

Synthetic phosphopeptide conjuagted to KLHEpitope: phosphotyrosine 416AA Sequence: DNEpYTAR

克隆位点

9A6

亚型

IgG3

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应用备注

Western Blot: 0.5 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. ELISA: 0.05 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
溶解方式

Restore with 1.0 mL H2O (15 min, RT).

缓冲液

2 x PBS / 0.09 % Sodium Azide / PEG and Sucrose.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

For long-term storage, freeze lyophilizate upon arrival (-20 °C). Upon reconstitution, aliquote and freeze in liquid nitrogen, reconstituted antibody can bestored frozen at -80 °C up to 1 year. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months. Avoid repeated freezing and thawing.

有效期

12 months
抗原

NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

别名

SRC1 (NCOA1 产品)

别名

F-SRC-1 antibody, KAT13A antibody, RIP160 antibody, SRC1 antibody, bHLHe42 antibody, bHLHe74 antibody, si:dkey-5g7.6 antibody, si:dkey-34f16.6 antibody, NCOA1 antibody, SRC-1 antibody, nuclear receptor coactivator 1 antibody, NCOA1 antibody, ncoa1 antibody, Ncoa1 antibody

背景

Src is the best understood member of a family of 9 tyrosine kinases regulating cellular responses to extracellular stimuli. Src is activated by PDGF and other growth factors that activate transmembrane tyrosine kinase receptors as well as increased intracellular calcium or oxidative stress. Src becomes activated upon dephosphorylation of Tyr 527, leading to a conformational change of the src molecule towards an "open", active conformation which allows binding to other proteins via the SH2 and SH3 domain. Activated src phosphorylates a variety of substrates involved in the mitogenic signalling pathway, cytoskeletal organization, cell-substrate adhesion, cell-cell adhesion, cell-cell communication, and RNA processing.Synonyms: Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, c-Src, pp60c-src

基因ID

6714

UniProt

P12931

途径

Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha