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CD8 抗体 (FITC)

CD8 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-31 FITC
产品编号 ABIN120695
发货至: 中国
  • 抗原 See all CD8 抗体
    CD8
    适用
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    宿主
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    小鼠
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    单克隆
    标记
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    This CD8 antibody is conjugated to FITC
    应用范围
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    Flow Cytometry (FACS)
    特异性
    The antibody recognizes a conformationally-dependent epitope of CD8 antigen (does not react with formaldehyde-fixed cells, negative in Western Blotting application).
    交叉反应 (详细)
    Species reactivity (tested):Human.
    产品特性
    Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain
    免疫原
    Crude thymus membrane fraction.
    克隆位点
    MEM-31
    亚型
    IgG2a
    Top Product
    Discover our top product CD8 Primary Antibody
  • 应用备注
    Flow Cytometry: Human blood cells using 20 μL reagent / 100 μL whole blood or 10^6 cellsin a suspension. Does not work in Immunohistochemistry on formalin fixed cells or Western blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade protease free BSA as a stabilizing agent.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody at 2-8 °C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    CD8
    别名
    CD8 (CD8 产品)
    别名
    CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, CD8a molecule antibody, CD8A antibody
    背景
    The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
    基因ID
    925
    UniProt
    P01732
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