This antibody recognizes KIR2D members of the killer cell immunoglobulin (Ig)-like receptor (KIR) family, CD158a, CD158b and P50.3. Clone NKVFS1 specifically recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). The clone is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms. We recommend the use of SM2036A for this purpose.
KIR2D family members are cell surface glycoproteins with two Ig domains, which are expressed on natural killer cells and some T cells.Synonyms: CD158a, CD158b, CD158i, KI2DL1, KILLER CELL Immunoglobin-Like Receptors, KIR2DL3, KIR2DS4