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- 抗原 See all IL2RG 抗体
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This IL2RG antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Neutralization (Neut)
- 品牌
- BD Pharmingen™
- 产品特性
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Neutralization Activity: Neutralization activity may be measured with a proliferation assay using 60 pg/mL recombinant human IL-15 (Cat. No. 560254) to stimulate murine CTLL-2 cells at 2x10^4 cells/mL as indicator cells (i.e preincubation of the antibody with recombinant human IL-15 for 60 minutes).
50% Neutralization (ND50) at 0.02 - 3.0 µg/mL
> 85% Neutralization at 2-20 µg/mL - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 克隆位点
- 4G3
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product IL2RG Primary Antibody
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 1, pp. 9-12, (1995) (PubMed).
: "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1596-605, (1995) (PubMed).
: "Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 15, Issue 5, pp. 447-54, (1995) (PubMed).
: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." in: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, (1994) (PubMed).
: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4." in: Science (New York, N.Y.), Vol. 262, Issue 5141, pp. 1874-7, (1994) (PubMed).
: "T cell growth factor: parameters of production and a quantitative microassay for activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 120, Issue 6, pp. 2027-32, (1978) (PubMed).
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The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 1, pp. 9-12, (1995) (PubMed).
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- 抗原
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
- 别名
- CD132 (IL2RG 产品)
- 别名
- Ab2-183 antibody, Cd132 antibody, CD132 antibody, CIDX antibody, IL-2RG antibody, IMD4 antibody, P64 antibody, SCIDX antibody, SCIDX1 antibody, [g]c antibody, gamma(c) antibody, gc antibody, interleukin 2 receptor subunit gamma antibody, interleukin 2 receptor subunit gamma L homeolog antibody, interleukin 2 receptor, gamma chain antibody, IL2RG antibody, il2rg.L antibody, Il2rg antibody
- 背景
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The 4G3 antibody reacts with the common gamma subunit (gammac) shared by the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors also known as CD132. This receptor is expressed constitutively at low levels on most lymphocytes, myeloid cells, embryonic thymocytes and lymphoid cell lines, but not non-lymphoid cells. The gammac receptor is a 75 - 80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated.
Synonyms: Common gamma chain, gammac - 途径
- JAK/STAT Signaling, Growth Factor Binding
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