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HLA-ABC 抗体

HLA-ABC 适用: 人 FACS, BR 宿主: 小鼠 Monoclonal DX17 unconjugated
产品编号 ABIN1177256
发货至: 中国
  • 抗原 See all HLA-ABC 抗体
    HLA-ABC
    适用
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    宿主
    • 56
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    小鼠
    克隆类型
    • 58
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    单克隆
    标记
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    This HLA-ABC antibody is un-conjugated
    应用范围
    • 53
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    Flow Cytometry (FACS), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    过滤
    0.2 μm filtered
    内毒素水平
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    免疫原
    Polyclonal Human NK Cell Line
    克隆位点
    DX17
    亚型
    IgG1 kappa
    Top Product
    Discover our top product HLA-ABC Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    储存液
    Azide free
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, (1995) (PubMed).

    Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, (1995) (PubMed).

    Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, (1984) (PubMed).

    Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8 (PubMed).

  • 抗原
    HLA-ABC
    别名
    HLA-A/B/C (HLA-ABC 产品)
    别名
    HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody
    背景
    The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.
    途径
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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