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CD73 抗体 (PE)

NT5E 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal AD2 PE
产品编号 ABIN1176840
发货至: 中国
  • 抗原 See all CD73 (NT5E) 抗体
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    适用
    • 107
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    • 18
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    人, Non-Human Primate
    宿主
    • 88
    • 29
    • 9
    • 2
    小鼠
    克隆类型
    • 79
    • 49
    单克隆
    标记
    • 54
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    This CD73 antibody is conjugated to PE
    应用范围
    • 80
    • 50
    • 44
    • 38
    • 15
    • 14
    • 14
    • 12
    • 9
    • 7
    • 5
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    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on the surface of T and B cell subsets, follicular dendritic cells and endothelial cells.
    交叉反应 (详细)
    Human
    纯化方法
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    pre-B leukemia cells
    克隆位点
    AD2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product NT5E Primary Antibody
  • 应用备注
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    说明

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    限制
    仅限研究用
  • 溶解方式
    No reconstitution is necessary.
    缓冲液
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    Avoid prolonged exposure to light.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Goričan, Gole, Potočnik: "Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening." in: Cells, Vol. 9, Issue 7, (2020) (PubMed).

    Semenov, Koestenbauer, Riegel, Zech, Zimmermann, Zisch, Malek: "Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation." in: American journal of obstetrics and gynecology, Vol. 202, Issue 2, pp. 193.e1-193.e13, (2010) (PubMed).

    Mokry, Soukup, Micuda, Karbanova, Visek, Brcakova, Suchanek, Bouchal, Vokurkova, Ivancakova: "Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells." in: Journal of biomedicine & biotechnology, Vol. 2010, pp. 673513, (2010) (PubMed).

    Paquet-Fifield, Schlüter, Li, Aitken, Gangatirkar, Blashki, Koelmeyer, Pouliot, Palatsides, Ellis, Brouard, Zannettino, Saunders, Thompson, Li, Kaur: "A role for pericytes as microenvironmental regulators of human skin tissue regeneration." in: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2795-806, (2009) (PubMed).

    Kögler, Sensken, Airey, Trapp, Müschen, Feldhahn, Liedtke, Sorg, Fischer, Rosenbaum, Greschat, Knipper, Bender, Degistirici, Gao, Caplan, Colletti, Almeida-Porada, Müller, Zanjani, Wernet: "A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential." in: The Journal of experimental medicine, Vol. 200, Issue 2, pp. 123-35, (2004) (PubMed).

    Rodriguez, Paquet, Yang, Erle: "Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells." in: BMC immunology, Vol. 5, pp. 13, (2004) (PubMed).

    Hashikawa, Takedachi, Terakura, Saho, Yamada, Thompson, Shimabukuro, Murakami: "Involvement of CD73 (ecto-5'-nucleotidase) in adenosine generation by human gingival fibroblasts." in: Journal of dental research, Vol. 82, Issue 11, pp. 888-92, (2003) (PubMed).

    Nemoto, Tada, Shimauchi: "Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production." in: Journal of leukocyte biology, Vol. 72, Issue 3, pp. 538-45, (2002) (PubMed).

    Borrione, Peola, Mariani, Besostri, Mallone, Malavasi, Pileri, Massaia: "CD38 stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the phosphatidylinositol 3-kinase pathway and inducing CD73 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 10, pp. 6238-46, (1999) (PubMed).

  • 抗原
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    别名
    CD73 (NT5E 产品)
    别名
    CALJA antibody, CD73 antibody, E5NT antibody, NT antibody, NT5 antibody, NTE antibody, eN antibody, eNT antibody, zgc:63784 antibody, NT5E antibody, MGC114869 antibody, PSPTO2277 antibody, 2210401F01Rik antibody, AI447961 antibody, Nt5 antibody, 5'-nucleotidase ecto antibody, 5'-nucleotidase, ecto (CD73) antibody, 5'-nucleotidase antibody, 5' nucleotidase, ecto antibody, NT5E antibody, nt5e antibody, nt5e.S antibody, PSPTO_2277 antibody, CBU_1233 antibody, MCA1322 antibody, Nt5e antibody
    背景
    5'-nucleotidase ecto,CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.,ecto-5´nucleotidase, NT5E, E5NT, CALJA, NTE
    基因ID
    4907
    UniProt
    P21589
    途径
    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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