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Caspase 1 p20 抗体

适用: 人 WB 宿主: 小鼠 Monoclonal Bally-1 unconjugated
产品编号 ABIN1169380
发货至: 中国
  • 抗原 See all Caspase 1 p20 products
    Caspase 1 p20
    适用
    • 50
    • 34
    • 32
    宿主
    • 49
    • 3
    小鼠
    克隆类型
    • 49
    • 3
    单克隆
    标记
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Caspase 1 p20 antibody is un-conjugated
    应用范围
    • 42
    • 36
    • 26
    • 26
    • 10
    • 9
    • 6
    • 2
    • 2
    • 2
    Western Blotting (WB)
    特异性
    Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
    交叉反应
    纯化方法
    Purified from concentrated hybridoma tissue culture supernatant.
    纯度
    >95 % (SDS-PAGE)
    免疫原
    Recombinant human caspase-1.
    克隆位点
    Bally-1
    亚型
    IgG1
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    有效期
    12 months
  • Rolfes, Ribeiro, Hawwari, Böttcher, Rosero, Maasewerd, Santos, Próchnicki, Silva, Wanderley, Rothe, Schmidt, Stunden, Bertheloot, Rivas, Fontes, Carvalho, Cunha, Latz, Arditi, Franklin: "Platelets Fuel the Inflammasome Activation of Innate Immune Cells." in: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).

    Hamarsheh, Osswald, Saller, Unger, De Feo, Vinnakota, Konantz, Uhl, Becker, Lübbert, Shoumariyeh, Schürch, Andrieux, Venhoff, Schmitt-Graeff, Duquesne, Pfeifer, Cooper, Lengerke, Boerries, Duyster et al.: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." in: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).

    Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." in: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

    Wu, Lu, Zhang, Zhang, Shi, Hisada, Grover, Zhang, Li, Xiang, Shi, Li, Daugherty, Smyth, Kirchhofer, Shiroishi, Shao, Mackman, Wei, Li: "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." in: Immunity, Vol. 50, Issue 6, pp. 1401-1411.e4, (2019) (PubMed).

    Mehto, Jena, Nath, Chauhan, Kolapalli, Das, Sahoo, Jain, Taylor, Chauhan: "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy." in: Molecular cell, Vol. 73, Issue 3, pp. 429-445.e7, (2019) (PubMed).

    Honda, Sadatomi, Yamamura, Nakashioya, Tanimura, Takeda: "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3." in: Cancer science, Vol. 108, Issue 3, pp. 520-527, (2017) (PubMed).

    Gaidt, Ebert, Chauhan, Ramshorn, Pinci, Zuber, ODuill, Schmid-Burgk, Hoss, Buhmann, Wittmann, Latz, Subklewe, Hornung: "The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3." in: Cell, Vol. 171, Issue 5, pp. 1110-1124.e18, (2017) (PubMed).

    Derangère, Chevriaux, Courtaut, Bruchard, Berger, Chalmin, Causse, Limagne, Végran, Ladoire, Simon, Boireau, Hichami, Apetoh, Mignot, Ghiringhelli, Rébé: "Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells." in: Cell death and differentiation, Vol. 21, Issue 12, pp. 1914-24, (2014) (PubMed).

  • 抗原
    Caspase 1 p20
    别名
    Caspase-1 p20 (Caspase 1 p20 产品)
    背景
    Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
    UniProt
    P29466
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