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IL1RL1 抗体

IL1RL1 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1169349
发货至: 中国
  • 抗原 See all IL1RL1 抗体
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This IL1RL1 antibody is un-conjugated
    应用范围
    • 33
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    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    特异性
    Recognizes soluble human ST2. Detects a band of ~50 kDa by Western blot and the endogenous ST2 by Flow Cytometry.
    交叉反应
    过滤
    0.2 μm filtered
    免疫原
    Recombinant human soluble ST2.
    Top Product
    Discover our top product IL1RL1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    In PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
    别名
    ST2 (IL1RL1 产品)
    别名
    DER4 antibody, Fit-1 antibody, Ly84 antibody, ST2L antibody, St2 antibody, St2-rs1 antibody, T1 antibody, T1/ST2 antibody, FIT-1 antibody, IL33R antibody, ST2 antibody, ST2V antibody, FIT1 antibody, interleukin 1 receptor-like 1 antibody, interleukin 1 receptor like 1 antibody, Il1rl1 antibody, IL1RL1 antibody
    背景
    ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
    UniProt
    Q01638
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