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- 抗原 See all IL-33 (IL33) 抗体
- IL-33 (IL33) (Interleukin 33 (IL33))
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IL-33 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- Recognizes mouse IL-33. Detects a band of ~18 kDa by Western blot.
- 交叉反应
- 小鼠
- 无交叉反应
- 人
- 交叉反应 (详细)
- Does not cross-react with human IL-33.
- 过滤
- 0.2 μm filtered
- 免疫原
- Recombinant mouse IL-33.
- Top Product
- Discover our top product IL33 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
- 储存液
- Without preservative
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26369-80, (2007) (PubMed).
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Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26369-80, (2007) (PubMed).
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- 抗原
- IL-33 (IL33) (Interleukin 33 (IL33))
- 别名
- IL-33 (IL33 产品)
- 别名
- IL33 antibody, C9orf26 antibody, DVS27 antibody, IL1F11 antibody, NF-HEV antibody, NFEHEV antibody, RP11-575C20.2 antibody, 9230117N10Rik antibody, Il-33 antibody, Il1f11 antibody, RGD1311155 antibody, interleukin 33 antibody, IL33 antibody, Il33 antibody
- 背景
- Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- UniProt
- Q8BVZ5
- 途径
- Production of Molecular Mediator of Immune Response
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