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LAG3 抗体 (N-Term)

Name: LAG3 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN1169105
Availability: OutOfStock

LAG3 适用: 人 WB, IHC, FACS, ICC, IP, Func 宿主: 小鼠 Monoclonal 17B4 unconjugated

Representative example and average expression of the indicated inhibitory receptorson MAIT cells over time in culture (n = 6–8) using LAG-3 antibody (ABIN1169105). (LAG3 抗体 (N-Term))

Func

1 image

(8 references)

产品编号 ABIN1169105

发货至: 中国

Datasheet as PDF

抗原 See all LAG3 抗体

LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
抗原表位
15

13

9

7

7

4

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
86

34

9

4

3

2

1

1

1
人
宿主
52

33

8

4
小鼠
Compatible Secondaries
克隆类型
53

41

1
单克隆
标记
52

6

6

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This LAG3 antibody is un-conjugated
应用范围
67

36

30

27

23

20

15

13

12

10

9

5

5

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunoprecipitation (IP), Functional Studies (Func)

特异性

Recognizes human LAG-3.

交叉反应

人

纯度

>95 % (SDS-PAGE)

内毒素水平

<0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).

免疫原

Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

克隆位点

17B4

亚型

IgG1

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anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody
LAG3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21775 unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody
LAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibody
LAG3 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8B12E10 unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (N-Term) antibody
LAG3 适用: 人 WB, ELISA, IHC, FACS, ICC, IP 宿主: 小鼠 Monoclonal L4-PL33 unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibody
LAG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibody
LAG3 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 244-487) antibody
LAG3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 209-451) antibody
LAG3 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibody
LAG3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

In PBS containing 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

有效期

12 months
Triebel, Hacene, Pichon: "A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors." in: Cancer letters, Vol. 235, Issue 1, pp. 147-53, (2006) (PubMed).

Maçon-Lemaître, Triebel: "The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells." in: Immunology, Vol. 115, Issue 2, pp. 170-8, (2005) (PubMed).

Di Carlo, Cappello, Sorrentino, DAntuono, Pellicciotta, Giovarelli, Forni, Musiani, Triebel: "Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway." in: The Journal of pathology, Vol. 205, Issue 1, pp. 82-91, (2004) (PubMed).

Demeure, Wolfers, Martin-Garcia, Gaulard, Triebel: "T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts." in: European journal of cancer (Oxford, England : 1990), Vol. 37, Issue 13, pp. 1709-18, (2001) (PubMed).

Hannier, Tournier, Bismuth, Triebel: "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 8, pp. 4058-65, (1998) (PubMed).

Huard, Mastrangeli, Prigent, Bruniquel, Donini, El-Tayar, Maigret, Dréano, Triebel: "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5744-9, (1997) (PubMed).

Huard, Gaulard, Faure, Hercend, Triebel: "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand." in: Immunogenetics, Vol. 39, Issue 3, pp. 213-7, (1994) (PubMed).

Baixeras, Huard, Miossec, Jitsukawa, Martin, Hercend, Auffray, Triebel, Piatier-Tonneau: "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens." in: The Journal of experimental medicine, Vol. 176, Issue 2, pp. 327-37, (1992) (PubMed).
抗原

LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

别名

LAG-3 (LAG3 产品)

别名

CD223 antibody, LAG-3 antibody, Ly66 antibody, lymphocyte activating 3 antibody, lymphocyte-activation gene 3 antibody, LAG3 antibody, Lag3 antibody

背景

Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

UniProt

P18627

途径

Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints