NAMPT 抗体
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- 抗原 See all NAMPT 抗体
- NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))
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适用
- 人, 大鼠, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NAMPT antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 特异性
- Recognizes human, mouse and rat Nampt.
- 交叉反应
- 人, 小鼠, 大鼠
- 过滤
- 0.2 μm filtered
- 免疫原
- Recombinant human Nampt (visfatin/PBEF).
- 克隆位点
- OMNI379
- 亚型
- IgG2a
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
- 储存液
- Without preservative
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - 有效期
- 12 months
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Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia." in: Blood, Vol. 125, Issue 1, pp. 111-23, (2015) (PubMed).
: "SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice." in: Cell metabolism, Vol. 21, Issue 5, pp. 706-17, (2015) (PubMed).
: "Expression and regulation of nampt in human islets." in: PLoS ONE, Vol. 8, Issue 3, pp. e58767, (2013) (PubMed).
: "Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 376-81, (2010) (PubMed).
: "Molecular characteristics of serum visfatin and differential detection by immunoassays." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 12, pp. 4783-91, (2007) (PubMed).
: "Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme." in: Cell metabolism, Vol. 6, Issue 5, pp. 363-75, (2007) (PubMed).
: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." in: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, (2006) (PubMed).
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Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia." in: Blood, Vol. 125, Issue 1, pp. 111-23, (2015) (PubMed).
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- 抗原
- NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))
- 别名
- Nampt (Visfatin/PBEF) (NAMPT 产品)
- 背景
- Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
- UniProt
- P43490
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