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Ezrin 抗体 (AA 362-585)

Name: Ezrin 抗体 (AA 362-585)
SKU: ABIN115202
Availability: OutOfStock

EZR 适用: 人, 小鼠, 大鼠, Cow, Hamster, Kangaroo WB, IP, IHC (p) 宿主: 小鼠 Monoclonal 3C12 unconjugated

Formalin fixed paraffin embedded human lung stained with Ezrin antibody. (Ezrin 抗体 (AA 362-585))

IHC

1 image

(6 references)

产品编号 ABIN115202

发货至: 中国

Datasheet as PDF

抗原 See all Ezrin (EZR) 抗体

Ezrin (EZR)
抗原表位
28

16

10

9

9

9

6

5

5

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 362-585
适用
139

78

68

8

8

6

6

4

4

3

3

1

1
人, 小鼠, 大鼠, Cow, Hamster, Kangaroo
宿主
130

8

3

2
小鼠
Compatible Secondaries
克隆类型
124

18
单克隆
标记
89

6

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1
This Ezrin antibody is un-conjugated
应用范围
116

55

26

17

15

13

13

13

10

8

3

2

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

This antibody reacts with a protein of 81 kDa.
Cellular Localization: Cell membrane

纯化方法

Purified

免疫原

BALB/C mice were immunized with a recombinant fragment of human ezrin corresponding to amino acid 362-585.

克隆位点

3C12

亚型

IgG1

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anti-Ezrin (EZR) (AA 1-295) antibody
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anti-Ezrin (EZR) (AA 1-586) antibody
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anti-Ezrin (EZR) (pTyr478) antibody
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anti-Ezrin (EZR) (AA 1-586) antibody
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anti-Ezrin (EZR) (AA 350-470) antibody
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anti-Ezrin (EZR) (AA 455-586) antibody
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anti-Ezrin (EZR) (AA 1-251) antibody
EZR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Immunoprecipitation. Western blot: 1: 100-750. Immunohistochemistry on paraffin embedded sections: dilute 1: 50-1: 100 in an ABC method(30 minutes at room temperature). Recommended positive control: Lung.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
状态

Liquid

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Hatano, Akiyama, Tamura, Hosogi, Marunaka, Caplan, Ueno, Tsukita, Asano: "Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice." in: Hepatology (Baltimore, Md.), Vol. 61, Issue 5, pp. 1660-71, (2015) (PubMed).

van Steensel, Paridaens, van Meurs, van Hagen, van den Bosch, Kuijpers, Drexhage, Hooijkaas, Dik: "Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 3, pp. E400-8, (2012) (PubMed).

Fonseca, Freund, Bornhäuser, Corbeil: "Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31661-71, (2010) (PubMed).

Gouas, Shi, Hautefeuille, Ortiz-Cuaran, Legros, Szymanska, Galy, Egevad, Abedi-Ardekani, Wiman, Hantz, Caron de Fromentel, Chemin, Hainaut: "Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein." in: Carcinogenesis, Vol. 31, Issue 8, pp. 1475-82, (2010) (PubMed).

Asari, Kanemitsu, Kurihara: "Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24751-8, (2010) (PubMed).

Geissler, Dashkevich, Fischer, Fries, Kuhn-Régnier, Addicks, Mehlhorn, Bloch: "First year changes of myocardial lymphatic endothelial markers in heart transplant recipients." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 29, Issue 5, pp. 767-71, (2006) (PubMed).
抗原

Ezrin (EZR)

别名

Ezrin (EZR 产品)

背景

Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.Synonyms: Cytovillin, EZR, VIL2, Villin-2, p81

基因ID

7430

NCBI登录号

NP_001104547

UniProt

P15311

途径

Maintenance of Protein Location