Aflatoxin 抗体
AFT
适用: Aspergillus
EIA
宿主: 大鼠
Monoclonal
1C6
unconjugated
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- 抗原 See all Aflatoxin (AFT) products
- Aflatoxin (AFT)
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适用
- Aspergillus
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This Aflatoxin antibody is un-conjugated
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应用范围
- Enzyme Immunoassay (EIA)
- 纯化方法
- Affinity Chromatography on protein G
- 免疫原
- Aflatoxin M1-BSA conjugate
- 克隆位点
- 1C6
- 亚型
- IgG2b
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- 应用备注
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ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 溶解方式
- Restore in double distillated water to adjust the final concentration to 1.0 mg/mL
- 浓度
- 1.0 mg/mL
- 缓冲液
- 0.01 M PBS, pH 7.2 without preservatives
- 储存液
- Without preservative
- 注意事项
- This product is photosensitive and should be protected from light
- 储存条件
- 4 °C
- 储存方法
- Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- 抗原
- Aflatoxin (AFT)
- 别名
- Aflatoxin (AFT 产品)
- 物质类
- Chemical
- 背景
- The aflatoxins are a group of closely related mycotoxins that are widely distributed in nature. The most important of the group is aflatoxin B1 (AFB1), which has a range of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity. In order for AFB1 to exert its effects, it must be converted to its reactive epoxide by the action of the mixed function mono-oxygenase enzyme systems (cytochrome P450-dependent) in the tissues (in particular, the liver) of the affected animal. This epoxide is highly reactive and can form derivatives with several cellular macromolecules, including DNA, RNA and protein. Cytochrome P450 enzymes may additionally catalyse the hydroxylation (to AFQ1 and AFM1) and demethylation (to AFP1) of the parent AFB1?Molecule, resulting in products less toxic than AFB1. Conjugation of AFB1 to glutathione (mediated by glutathione S-transferase) and its subsequent excretion is regarded as an important detoxification pathway in animals.
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