Apo(a) 抗体
apo(a)
适用: 哺乳动物
WB, EIA
宿主: 绵羊
Polyclonal
unconjugated
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- 抗原 See all Apo(a) (apo(a)) 抗体
- Apo(a) (apo(a)) (Apolipoprotein A (apo(a)))
- 适用
- 哺乳动物
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宿主
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绵羊
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克隆类型
- 多克隆
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标记
- This Apo(a) antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- Specifically binds to human Lp(a) and apo(a). No cross-reaction to Apo B-100/48, minor to plasminogen.
- 纯化方法
- Human Apo (a) Sepharose affinity column. Cross-reactivity to plasminogen was removed by passing plasminogen Sepharose affinity column.
- Top Product
- Discover our top product apo(a) Primary Antibody
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- 应用备注
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Suitable for use in ELISA (1: 7,500-1: 60,000), Western blot and conjugation purposes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL (OD280nm, E0.1% = 1.35)
- 缓冲液
- 75 mM PBS, 75 m mM Sodium chloride, pH 7.2 containing 0.02 % Sodium azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- Apo(a) (apo(a)) (Apolipoprotein A (apo(a)))
- 别名
- Apolipoprotein(a) / LP(a) (apo(a) 产品)
- 别名
- AK38 antibody, APOA antibody, LP antibody, Apo(a) antibody, Lp(a) antibody, lipoprotein(a) antibody, LPA antibody
- 背景
- Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis.Synonyms: Apo(a), LPA
- 基因ID
- 4018
- NCBI登录号
- NP_005568
- UniProt
- P08519
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