BMP6 抗体 (N-Term) (Biotin)
-
- 抗原 See all BMP6 抗体
- BMP6 (Bone Morphogenetic Protein 6 (BMP6))
-
抗原表位
- AA 1-29, N-Term
-
适用
- 人, 大鼠
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This BMP6 antibody is conjugated to Biotin
-
应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody reacts with Bone morphogenic Protein-6 (BMP-6). Antigen specificity of morph-6.1: Pre-incubation of morph-6.1 with amino-terminal peptide 1-29 of BMP-6 inhibits binding of the mAb to tissue sections. Pre-incubation with other amino-terminal synthetic peptides of human BMP-7, BMP-4, BMP-3 and BMP-2 as well as an irrelevant peptide does not inhibit specific tissue staining. Antigen Distribution on Tissue Sections: Positive staining can be observed in embryonic and adult central nervous system. Rat radial glial cells of the developing central nervous system from E11 to E19. In rat peripheral nerves a selective intracellular immunoreactivity can be found in perinuclear region of most Schwann cells which form the myelin sheath. However, some Schwann cells were negative for morph-6.1. BMP-6 can also be found in a variety of other tissues and cell types, notably keratinizing epithelial cells. Smooth muscle cells, characterized by Desmin positivity, were positively stained in normal tissues and in atherosclerotic plaques. Macrophages (CD68+) and endothelial cells were negative with morph-6.1.
- 交叉反应 （详细）
- Species reactivity (tested):Rat, Human (Phylogenetically highly conserved antigen).
- 纯化方法
- Affinity Chromatography.
- 免疫原
- Aminoterminal synthetic peptide 1-29.
- 克隆位点
- Morph-6-1
- 亚型
- IgG1
- Top Product
- Discover our top product BMP6 Primary Antibody
-
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 375-502) antibody
BMP6 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 375-513) antibodyBMP6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) antibodyBMP6 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 382-513) antibodyBMP6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) antibodyBMP6 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 25-55), (N-Term) antibodyBMP6 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01862 unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 25-55) antibodyBMP6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 382-471) antibodyBMP6 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) (AA 359-408) antibodyBMP6 适用: 人, 大鼠, 小鼠, Cow, 犬, 山羊, 豚鼠, 马, 兔, 绵羊, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 6 (BMP6) antibody (HRP)BMP6 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
-
- 应用备注
-
Immunohistochemistry on Frozen Sections: 1-2 μg/mL (1/100-1/200). Immunohistochemistry on Paraffin Sections (Microwave pretreatment for antigen retrievalis recommended). Recommended Dilutions: Rat Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
-
- 溶解方式
- Restore with 0.5 mL distilled water.
- 浓度
- 0.2 mg/mL
- 缓冲液
- PBS, pH 7.2 with 0.09 % Sodium Azide as preservative and 5 mg/mL BSA as stabilizer
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Dilute only prior to immediate use
- 储存条件
- 4 °C
- 储存方法
- Store the antibody at 2-8 °C as an undiluted liquid. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
-
- 抗原
- BMP6 (Bone Morphogenetic Protein 6 (BMP6))
- 别名
- BMP6 (BMP6 产品)
- 背景
- Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. BMP6 is an autocrine stimulator of chondrocyte differentiation and has been implicated in the development of embryonic kidney and urinary systems. It is involved in liver growth and differentiation, keratinocyte differentiation, and regulation of neuronal tissue development. BMP6 expression is localized to smooth muscle cells of normal cerebral blood vessels, intimal plaques and atherosclerotically changed blood vessels, further suggesting a role as a regulator of developing tissues. BMP-6 is a member of the TGF-beta superfamily of cytokines regulating homeotic gene expression, embryonic development and neurogenesis.Synonyms: BMP-6, Bone morphogenetic protein 6, VGR, VGR1
- 基因ID
- 25644
- NCBI登录号
- NP_037239
- UniProt
- Q04906
- 途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
-
