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CD38 抗体 (PE-DyLight 594)

Name: CD38 抗体 (PE-DyLight 594)
Brand: antibodies-online
SKU: ABIN1111103
Availability: OutOfStock

适用: 人 FACS 宿主: 小鼠 Monoclonal HIT2 PE-DyLight 594

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD38 (HIT2) PE-DyLight® 594 (4 μL reagent / 100 μL of peripheral whole blood). (CD38 抗体 (PE-DyLight 594))

FACS

Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE. (CD38 抗体 (PE-DyLight 594))

FACS

Separation of human CD38 positive monocytes (red-filled) from human CD38 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD38 (HIT2) PE-DyLight® 594 (4 μL reagent / 100 μL of peripheral whole blood). (CD38 抗体 (PE-DyLight 594))

FACS

3 images

(3 references)

产品编号 ABIN1111103

发货至: 中国

Datasheet as PDF

抗原 See all CD38 抗体

CD38
适用
170

62

22

12

12

12

1

1
人
宿主
108

87

28

1

1
小鼠
Compatible Secondaries
克隆类型
147

74

2
单克隆
标记
65

16

15

14

11

8

6

5

5

4

4

4

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This CD38 antibody is conjugated to PE-DyLight 594
应用范围
167

64

42

31

30

26

26

21

19

19

7

7

3

2

1

1

1

1

1

1
Flow Cytometry (FACS)

特异性

The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

交叉反应（详细）

Human

纯化方法

Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-DyLight®594 (PE-DyLight®594) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

免疫原

Human thymocytes in foetus

克隆位点

HIT2

亚型

IgG1

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anti-CD38 (AA 101-200) antibody
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应用备注

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

说明

The purified antibody is conjugated with tandem dye PE-DyLight™, 594 (PE-DL594) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

限制

仅限研究用
溶解方式

No reconstitution is necessary.

缓冲液

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Do not freeze.
Avoid prolonged exposure to light.

储存条件

4 °C

储存方法

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

Rozková, Novotná, Pytlík, Hochová, Kozák, Bart?nková, Spísek: "Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1132-43, (2010) (PubMed).

Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." in: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).
抗原

CD38

Abstract

CD38 产品

别名

T10 antibody, Cd38-rs1 antibody, cd38 antibody, ADPRC 1 antibody, cADPr hydrolase 1 antibody, CD38 molecule antibody, CD38 antigen antibody, CD38 molecule L homeolog antibody, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 antibody, CD38 antibody, Cd38 antibody, cd38.L antibody

背景

CD38 Molecule,CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.,ADPRC1, cADPr hydrolase 1, T10, NAD(+) nucleosidase, ADP-ribosyl cyclase 1

基因ID

952

UniProt

P28907