Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
特异性
This antibody detects PMVK (mid region). No cross reactivity with other proteins.
交叉反应 (详细)
Species reactivity (tested):Human, Mouse, Rat.
纯化方法
Immunoaffinity Chromatography
免疫原
Synthetic peptide corresponding to a sequence mapping at the middle region of Human PMVK .Remarks: Sequence is different from the related Mouse and Rat sequence by single amino acid.
PMVK (phosphomevalonate kinase) is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.Synonyms: HUMPMKI, PMKI, PMKase, Phosphomevalonate kinase