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MTDH 抗体

MTDH 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 2F11C3 unconjugated
产品编号 ABIN1108306
发货至: 中国
  • 抗原 See all MTDH 抗体
    MTDH (Metadherin (MTDH))
    适用
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 41
    • 6
    • 3
    小鼠
    克隆类型
    • 46
    • 4
    单克隆
    标记
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This MTDH antibody is un-conjugated
    应用范围
    • 40
    • 15
    • 13
    • 13
    • 11
    • 10
    • 8
    • 8
    • 7
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to Metadherin.
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Affinity chromatography on Protein G
    克隆位点
    2F11C3
    亚型
    IgG1
    Top Product
    Discover our top product MTDH Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS, 0,03 % sodium azide, 50 % glycerol
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • 抗原
    MTDH (Metadherin (MTDH))
    别名
    MTDH (MTDH 产品)
    别名
    MGC75963 antibody, 2610103J23Rik antibody, 3D3 antibody, 3D3/Lyric antibody, AEG-1 antibody, AV353288 antibody, D8Bwg1112e antibody, Lyric antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, metadherin antibody, mtdh antibody, MTDH antibody, Mtdh antibody
    背景
    Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.Synonyms: 3D3/LYRIC, AEG-1, AEG1, Astrocyte elevated gene-1 protein, LYRIC, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein
    分子量
    64 kDa
    基因ID
    92140
    途径
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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