MICA 抗体
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- 抗原 See all MICA 抗体
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MICA antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), ELISA (Detection)
- 特异性
- This antibody reacts with MICA/B.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Protein A agarose
- 免疫原
- MICA*01, MICA*04 and MICB*02 transfected P815 cells
- 克隆位点
- BAMO3
- 亚型
- IgG2a
- Top Product
- Discover our top product MICA Primary Antibody
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anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 68-97) antibody
MICA 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB21777 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 120-170) antibodyMICA 适用: 人 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) (AA 1-200) antibodyMICA 适用: 人 WB, IHC (f) 宿主: 小鼠 Monoclonal unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-147 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), CyTOF 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibodyMICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro), Func, CyTOF 宿主: 小鼠 Monoclonal W6-32 unconjugated
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (FITC)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 FITC
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (Biotin)MICA 适用: 人, Cow, Cat, Non-Human Primate ELISA, FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal W6-32 Biotin
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人, Cow, Cat, Non-Human Primate FACS 宿主: 小鼠 Monoclonal W6-32 PE
anti-MHC Class I Polypeptide-Related Sequence A (MICA) antibody (PE)MICA 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-147 PE
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 50 % Glycerol, pH 7.2, None
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store (in aliquots) at -20 °C.
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- 抗原
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- 别名
- MICA (MICA 产品)
- 别名
- MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
- 背景
- MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is ex pressed on NK (Natural Killer) cells, NKT cells, gamma delta Tau cells and CD8 + alpha beta tau cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, and sMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.Synonyms: MHC class I polypeptide-related sequence A, MHC class I polypeptide-related sequence B, MIC-A, MIC-B, PERB11.1, PERB11.2
- 基因ID
- 100507436
- NCBI登录号
- NP_000238
- UniProt
- Q29983
- 途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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