C-QESVKQAHLR NEH Remarks: Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Marmoset (100%), Monkey (92%), Mouse (92%), Rat (92%), Hamster (92%), Elephant (92%), Dog (92%), Horse (92%), Rabbit (92%), Opossum (92%), Platypus (92%), Panda (85%), Bat (85%), Turkey (85%), Chicken (85%).
特异性
This antibody is expected to recognize reported isoform I (NP_004406.2) only.
交叉反应 (详细)
Species reactivity (expected):Mouse, Rat. Species reactivity (tested):Human.
纯化方法
Immunoaffinity Chromatography
免疫原
Synthetic peptide from the internal region of Human DSP / Desmoplakin (NP_004406.2). Genename: DSP
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP