CD209b Antigen (CD209B) 抗体
(1 reference)-
- 抗原 See all CD209b Antigen (CD209B) 抗体
- CD209b Antigen (CD209B)
- 适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody recognises SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human DC-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations. Like many C-type lectins, SIGN-R1 functions as a pathogen recognition receptor in vivo and plays an important role in defence against pathogens. Antibodies, produced by clone ER-TR9, are reported to block the uptake of neutral polysaccharides by macrophages.
- 纯化方法
- Ammonium sulphate precipitation
- 内毒素水平
- Low Endotoxin
- 免疫原
- Isolated C3H thymic stromal cells. - Spleen cells from immunised rats were fused with cells of the Mouse P3-X63-Ag8.563 myeloma cell line.
- 克隆位点
- ER-TR9
- 亚型
- IgM
- Top Product
- Discover our top product CD209B Primary Antibody
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anti-CD209b Antigen (CD209B) (AA 51-150) antibody
CD209B 适用: 小鼠 WB, IF (cc), IF (p), IHC (fro), IHC (p), ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD209b Antigen (CD209B) antibody (APC)CD209B 适用: 小鼠 FACS 宿主: Armenian Hamster Monoclonal 22D1 APC
anti-CD209b Antigen (CD209B) antibody (PE)CD209B 适用: 小鼠 FACS 宿主: Armenian Hamster Monoclonal 22D1 PE
anti-CD209b Antigen (CD209B) antibodyCD209B 适用: 小鼠 FACS, IHC (fro) 宿主: 大鼠 Monoclonal ER-TR9 unconjugated
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- 应用备注
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Flow Cytometry: 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunohistochemistry on frozen sections: 1/25 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store the antibody at -20 °C only.
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: "Unique requirements for reactivation of virus-specific memory B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4011-21, (2010) (PubMed).
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: "Unique requirements for reactivation of virus-specific memory B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4011-21, (2010) (PubMed).
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- 抗原
- CD209b Antigen (CD209B)
- 别名
- CD209b / DC-SIGNR1 (CD209B 产品)
- 背景
- SIGN R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. MZM of the spleen are involved in the clearance of polysaccharides. Mouse SIGN R1 is a C type lectin, like DC SIGN which is expressed on Human dendritic cells (DCs). However, Mmouse SIGN R1 itself is not expressed on DCs. SIGN R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides.Synonyms: CD209 antigen-like protein B, DC-SIGN-related protein 1, OtB7
- 基因ID
- 69165
- NCBI登录号
- NP_001032889
- UniProt
- Q8CJ91
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