The antibody reacts with Very Low Density Lipoproteins (VLDL) of Human plasma. It is specific for Human Apo-E. No crossreactions with other Human plasma proteins were detected. This antibody reacts as well with LDL as with VLDL. This antibody recognizes all alleles of Apo-E. In combination with other mabs for detection of VLDL in plasma, and for the specific detection of Apo-E. The antibody is also useful for detection of Apo-E in tissue sections.
Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.Synonyms: Apo-E, ApoE