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STAT5A 抗体 (AA 583-794)

STAT5A 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6D4 unconjugated
产品编号 ABIN1098129
发货至: 中国
  • 抗原 See all STAT5A 抗体
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    抗原表位
    • 35
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    • 9
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    AA 583-794
    适用
    • 181
    • 96
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    • 5
    • 3
    • 3
    • 3
    • 1
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    宿主
    • 162
    • 20
    • 2
    小鼠
    克隆类型
    • 153
    • 31
    单克隆
    标记
    • 106
    • 10
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    This STAT5A antibody is un-conjugated
    应用范围
    • 153
    • 65
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    原理
    STAT5A Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human STAT5A (AA: 583-794 ) expressed in E. Coli.
    克隆位点
    6D4
    亚型
    IgG1
    Top Product
    Discover our top product STAT5A Primary Antibody
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/50

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Cerliani, Guillardoy, Giulianelli, Vaque, Gutkind, Vanzulli, Martins, Zeitlin, Lamb, Lanari: "Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer." in: Cancer research, Vol. 71, Issue 10, pp. 3720-31, (2011) (PubMed).

    Warsch, Kollmann, Eckelhart, Fajmann, Cerny-Reiterer, Hölbl, Gleixner, Dworzak, Mayerhofer, Hoermann, Herrmann, Sillaber, Egger, Valent, Moriggl, Sexl: "High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia." in: Blood, Vol. 117, Issue 12, pp. 3409-20, (2011) (PubMed).

  • 抗原
    STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
    别名
    STAT5A (STAT5A 产品)
    别名
    MGF antibody, STAT5 antibody, AA959963 antibody, Stat5 antibody, STAT5A/MGF antibody, STATA5 antibody, STAT5A antibody, stat5 antibody, stat5b antibody, signal transducer and activator of transcription 5A antibody, signal transducer and activator of transcription 5a antibody, STAT5A antibody, Stat5a antibody, stat5a antibody, LOC100348518 antibody, LOC100716811 antibody
    背景

    Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

    Aliases: MGF, STAT5

    分子量
    90.6kDa
    基因ID
    6776
    HGNC
    6776
    UniProt
    P42229
    途径
    JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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