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PIK3R1 抗体 (AA 159-388)

PI3K p85a 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 6G10 unconjugated
产品编号 ABIN1098111
发货至: 中国
  • 抗原 See all PIK3R1 (PI3K p85a) 抗体
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    抗原表位
    • 19
    • 16
    • 15
    • 13
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    • 8
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    AA 159-388
    适用
    • 129
    • 93
    • 67
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    • 6
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    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
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    宿主
    • 116
    • 28
    小鼠
    克隆类型
    • 106
    • 38
    单克隆
    标记
    • 72
    • 11
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    This PIK3R1 antibody is un-conjugated
    应用范围
    • 117
    • 57
    • 38
    • 28
    • 24
    • 17
    • 16
    • 12
    • 12
    • 6
    • 4
    • 2
    • 2
    • 1
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    ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    原理
    PIK3R1 Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.
    克隆位点
    6G10
    亚型
    IgG1
    Top Product
    Discover our top product PI3K p85a Primary Antibody
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/100

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Natunen, Martiskainen, Marttinen, Gabbouj, Koivisto, Kemppainen, Kaipainen, Takalo, Svobodová, Leppänen, Kemiläinen, Ryhänen, Kuulasmaa, Rahunen, Juutinen, Mäkinen, Miettinen, Rauramaa, Pihlajamäki et al.: "Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. ..." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 66, (2020) (PubMed).

    Kwon, Salinas, Kolb, Fu, Feng, Stanford, Ostrander: "Genetic polymorphisms in inflammation pathway genes and prostate cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 20, Issue 5, pp. 923-33, (2011) (PubMed).

    Taniguchi, Winnay, Kondo, Bronson, Guimaraes, Alemán, Luo, Stephanopoulos, Weissleder, Cantley, Kahn: "The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling." in: Cancer research, Vol. 70, Issue 13, pp. 5305-15, (2010) (PubMed).

  • 抗原
    PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
    别名
    PIK3R1 (PI3K p85a 产品)
    别名
    PI3CG antibody, PI3K antibody, PI3Kgamma antibody, PIK3 antibody, AGM7 antibody, GRB1 antibody, p85 antibody, p85-ALPHA antibody, PI3KA antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, wu:fb65b05 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antibody, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antibody, PIK3CG antibody, PIK3R1 antibody, Pik3r1 antibody, Pik3cb antibody, pik3r1 antibody
    背景

    Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.

    Aliases: p85, GRB1, p85-ALPHA

    分子量
    83.6kDa
    基因ID
    5295
    HGNC
    5295
    UniProt
    P27986
    途径
    TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect
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