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TGFB1 抗体 (N-Term)

TGFB1 适用: 人 WB, ELISA, FM 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN107740
发货至: 中国
  • 抗原 See all TGFB1 抗体
    TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
    抗原表位
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    N-Term
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This TGFB1 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Fluorescence Microscopy (FM)
    原理
    TGF beta 1 Antibody
    交叉反应 (详细)
    Rabbit Anti-TGF beta 1 affinity purified antibody is directed against human TGFb1 protein.
    产品特性
    Synonyms: rabbit anti-TGFB1 antibody, rabbit anti-TGF beta 1 antibody, rabbit anti-TGF ß 1 antibody, Transforming growth factor beta-1, Latency-associated peptide, LAP, TGFB 1
    纯化方法
    The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    过滤
    Sterile filtered
    免疫原

    Immunogen: TGF beta 1 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of the mature growth factor (112 amino acids in length).

    Immunogen Type: Conjugated Peptide

    亚型
    IgG
    Top Product
    Discover our top product TGFB1 Primary Antibody
  • 应用备注

    Application Note: Anti-TGF beta 1 Antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 12.5 kDa in size corresponding to reduced mature TGFb1 by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:100 - 1:500

    ELISA Dilution: 1:10,000 - 1:20,000

    IF Microscopy Dilution: User Optimized

    Other: User Optimized

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.43 mg/mL
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • Filgueiras, Capelozzi, Martins, Jancar: "Sepsis-induced lung inflammation is modulated by insulin." in: BMC pulmonary medicine, Vol. 14, pp. 177, (2016) (PubMed).

  • 抗原
    TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
    别名
    TGFB1 (TGFB1 产品)
    背景
    Background: TGF-beta-1 is a multifunctional cytokine that belongs to a superfamily of structurally related regulatory proteins, including three mammalian TGF-beta isoforms (TGF-beta-1, -beta-2, and -beta-3), activin/inhibins and bone morphogenetic proteins. The most abundant isoform, TGF-beta-1, is a 25 kDa homodimer composed of two 12.5 kDa subunits joined by disulfide bonds. TGF-beta-1 is a highly conserved molecule, the amino acid sequence between human and mouse differs by only one residue. Although originally defined by its ability to cause anchorage independent cell growth and changes in cell morphology of rat fibroblasts, subsequent research has revealed that TGF-beta is actually a major growth inhibitor for most cell types. It is produced by a wide variety of cell and tissue types during all stages of cell differentiation. TGF-beta-1 sources include platelets, bone and soft tissues, such as placenta and kidneys.
    基因ID
    7040, 339558
    UniProt
    P01137
    途径
    EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
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