IDO1 抗体
(4 references)-
- 抗原 See all IDO1 抗体
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IDO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)
- 特异性
- Anti-IDO1 was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for human and mouse IDO1 protein. A BLAST analysis was used to suggest cross-reactivity with IDO1 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with IDO1 from other sources has not been determined.
- 产品特性
- Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
- 过滤
- Sterile filtered
- 免疫原
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Anti-IDO1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with fragment of recombinant human and mouse IDO1 protein followed by hybridoma development.
Immunogen Type: RecombinantProtein - 克隆位点
- 10-1
- 亚型
- IgG3
- Top Product
- Discover our top product IDO1 Primary Antibody
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anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibody
IDO1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibodyVerified IDO1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 人 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2E2-6 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibodyIDO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-100) antibodyIDO1 适用: 人, 小鼠 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 304-403) antibodyIDO1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C5 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibodyIDO1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 204-403) antibodyIDO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 小鼠 WB, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Anti-IDO1 antibody has been tested for use in ELISA, Western Blot, IP, IHC, and Flow Cytometry. Specific conditions for reactivity should be optimized by the end user.
- 说明
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Gene Name: Ido1
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- 有效期
- 12 months
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: "Evidence that the bulge region is a site of relative immune privilege in human hair follicles." in: The British journal of dermatology, Vol. 159, Issue 5, pp. 1077-85, (2009) (PubMed).
: "Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors." in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Vol. 11, Issue 6, pp. 460-6, (2009) (PubMed).
: "Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 11, pp. 8226-33, (2007) (PubMed).
: "IDO expression by dendritic cells: tolerance and tryptophan catabolism." in: Nature reviews. Immunology, Vol. 4, Issue 10, pp. 762-74, (2004) (PubMed).
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: "Evidence that the bulge region is a site of relative immune privilege in human hair follicles." in: The British journal of dermatology, Vol. 159, Issue 5, pp. 1077-85, (2009) (PubMed).
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- 抗原
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- 别名
- IDO1 (IDO1 产品)
- 别名
- INDO antibody, ido antibody, indo antibody, IDO antibody, cd107b antibody, IDO1 antibody, IDO-1 antibody, Ido antibody, Indo antibody, indoleamine 2,3-dioxygenase 1 antibody, indoleamine 2,3-dioxygenase 1 L homeolog antibody, indoleamine 2,3-dioxygenase 1-like antibody, IDO1 antibody, ido1.L antibody, ido1 antibody, Ido1 antibody, LOC100050681 antibody
- 背景
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Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
Synonyms: Ido, Indo, Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase, Ido1, Ido-1 - 基因ID
- 3620
- NCBI登录号
- NP_002155
- UniProt
- P14902
- 途径
- Activated T Cell Proliferation
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