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PPP2CA 抗体 (meLys309)

PPP2CA 适用: 人, 小鼠, 大鼠 WB, IP 宿主: 小鼠 Monoclonal 2A10 unconjugated
产品编号 ABIN1042659
发货至: 中国
  • 抗原 See all PPP2CA 抗体
    PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))
    抗原表位
    • 16
    • 14
    • 14
    • 8
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    meLys309
    适用
    • 72
    • 63
    • 54
    • 12
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 84
    • 5
    • 3
    • 2
    小鼠
    克隆类型
    • 85
    • 9
    单克隆
    标记
    • 54
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP2CA antibody is un-conjugated
    应用范围
    • 73
    • 28
    • 19
    • 18
    • 17
    • 14
    • 13
    • 13
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    序列
    KLH-C-ßA-RRTPDYFL-OMe
    特异性
    Recognises specifically the C-terminally methylated form of PP2A C subunit
    交叉反应
    Saccharomyces cerevisiae
    交叉反应 (详细)
    Mouse, Rat, Human. Predicted to work with: Saccharomyces cerevisiae
    纯化方法
    Protein G
    免疫原
    A KLH-coupled peptide with the sequence: KLH-C-ßA-RRTPDYFL-OMe. The c-terminal sequence (as well as the carboxy-methylation) is absolutely conserved from human, mouse to yeast
    克隆位点
    2A10
    亚型
    IgG1
    Top Product
    Discover our top product PPP2CA Primary Antibody
  • 应用备注
    Optimal antibody dilution should be determined by titration, however as a guideline try, WB: 1,500. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa)
    说明

    Myeloma, fusion partners: X63-Ag8.653

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Benziane, Björnholm, Pirkmajer, Austin, Kotova, Viollet, Zierath, Chibalin: "Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23451-63, (2012) (PubMed).

    Li, Huang, Liang, Fu, Guo, Xu: "Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by ?4 protein in HEK293 cells." in: International journal of biological sciences, Vol. 7, Issue 6, pp. 740-52, (2011) (PubMed).

    Finnegan, Mackey, Cotter: "A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A." in: The European journal of neuroscience, Vol. 32, Issue 3, pp. 322-34, (2010) (PubMed).

    Hombauer, Weismann, Mudrak, Stanzel, Fellner, Lackner, Ogris: "Generation of active protein phosphatase 2A is coupled to holoenzyme assembly." in: PLoS biology, Vol. 5, Issue 6, pp. e155, (2007) (PubMed).

    Sontag, Nunbhakdi-Craig, Sontag, Diaz-Arrastia, Ogris, Dayal, Lentz, Arning, Bottiglieri: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, (2007) (PubMed).

    Sontag, Hladik, Montgomery, Luangpirom, Mudrak, Ogris, White: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, (2004) (PubMed).

    Sontag, Luangpirom, Hladik, Mudrak, Ogris, Speciale, White: "Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 4, pp. 287-301, (2004) (PubMed).

    Fellner, Lackner, Hombauer, Piribauer, Mudrak, Zaragoza, Juno, Ogris: "A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo." in: Genes & development, Vol. 17, Issue 17, pp. 2138-50, (2003) (PubMed).

  • 抗原
    PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))
    别名
    PP2A alpha (PPP2CA 产品)
    别名
    PP2Ac antibody, PP2CA antibody, PP2Calpha antibody, RP-C antibody, PP2A antibody, R75353 antibody, Pp2a1 antibody, pp2ac antibody, zgc:110641 antibody, protein phosphatase 2 catalytic subunit alpha antibody, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform antibody, protein phosphatase 2, catalytic subunit, alpha isozyme antibody, protein phosphatase 2 catalytic subunit alpha L homeolog antibody, protein phosphatase 2, catalytic subunit, beta isozyme antibody, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody, PPP2CA antibody, Ppp2ca antibody, ppp2ca.L antibody, ppp2cb antibody, LOC471633 antibody, ppp2ca antibody
    背景
    Synonyms:
    PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody,PPP2CA antibody,Protein phosphatase 2, catalytic subunit, alpha isoform antibody,Replication protein C antibody
    基因ID
    5515, 19052, 24672
    OMIM
    176915
    UniProt
    P67775, P63330, P63331
    途径
    PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades
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