HLA DQ 抗体
(1 reference)-
- 抗原 See all HLA DQ (HLA-DQ) products
- HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
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适用
- 人, Pig
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HLA DQ antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
- 特异性
- NKI(SPV)L3 reacts with a monomorphic determinant on HLA-DQ (MHC class II).
- 产品特性
- Haematology
- 纯化方法
- Purified
- 克隆位点
- NKI(SPV)L3
- 亚型
- IgG2a
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anti-MHC Class II HLA-DQ (HLA-DQ) antibody
HLA-DQ 适用: 人, Pig FACS, IF, IHC (fro) 宿主: 兔 Monoclonal HLA-DQA1-2866R unconjugated Recombinant Antibody
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF 宿主: 小鼠 Monoclonal SPV-L3 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF, ELISA, Coat 宿主: 小鼠 Monoclonal SPM422 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
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- 应用备注
- NKI(SPV)L3 is used in research and human diagnostics, cell separation for research or clinical application. NKI(SPV)L3 is useful for immunoprecipitation, flow cytometry and immunohistochemsitry on frozen sections. Optimal antibody dilution should be determined by titration.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.09% sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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: "Impression procedures for the cleft palate patient." in: The Compendium of continuing education in dentistry, Vol. 4, Issue 5, pp. 423-7, (1983) (PubMed).
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: "Impression procedures for the cleft palate patient." in: The Compendium of continuing education in dentistry, Vol. 4, Issue 5, pp. 423-7, (1983) (PubMed).
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- 抗原
- HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
- 别名
- HLA DQ (HLA-DQ 产品)
- 背景
- HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an alphabeta heterodimer of the MHC Class II type. The alpha and beta chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the alpha-chain and beta-chain vary greatly. A person often produces two alpha-chain and two beta-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people.
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