GABBR1 抗体 (AA 873-977)
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- 抗原 See all GABBR1 抗体
- GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
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抗原表位
- AA 873-977
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GABBR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Detects ~115 kDa. No cross-reactivity against GABA(B)R2.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein G Purified
- 免疫原
- Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1
- 克隆位点
- S93A-49
- 亚型
- IgG1
- Top Product
- Discover our top product GABBR1 Primary Antibody
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anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody
GABBR1 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (C-Term) antibodyGABBR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) antibodyGABBR1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (HRP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 HRP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (FITC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 FITC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (Alkaline Phosphatase (AP))GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 Alkaline Phosphatase (AP)
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (Biotin)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 Biotin
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PE)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PE
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (APC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 APC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PerCP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PerCP
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- 应用备注
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- WB (1:1000)
- optimal dilutions for assays should be determined by the user.
- 说明
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1 μg/ml of ABIN1027717 was sufficient for detection of GABA(B)R1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
- 别名
- GABA B Receptor 1 (GABBR1 产品)
- 别名
- GABABR1 antibody, GABBR1-3 antibody, GB1 antibody, GPRC3A antibody, dJ271M21.1.1 antibody, dJ271M21.1.2 antibody, gabbr1 antibody, GABBR1 antibody, GABA(B)R1 antibody, GABAB1 antibody, GABAbR1 antibody, bM573K1.1 antibody, gamma-aminobutyric acid type B receptor subunit 1 antibody, gamma-aminobutyric acid (GABA) B receptor, 1a antibody, gamma-aminobutyric acid (GABA) B receptor, 1 antibody, GABBR1 antibody, gabbr1a antibody, gabbr1 antibody, Gabbr1 antibody
- 背景
- GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).
- 基因ID
- 81657
- NCBI登录号
- NP_112290
- UniProt
- Q9Z0U4
- 途径
- Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process
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