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Huntingtin 抗体 (pSer421)

Name: Huntingtin 抗体 (pSer421)
Brand: antibodies-online
SKU: ABIN100604
Availability: OutOfStock

HTT 适用: 人 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated

Western blot analysis after AKT and phosphatase treatment is shown using Affinity Purified anti-Huntingtin pS421 antibody. (Huntingtin 抗体 (pSer421))

Western blot analysis is shown using Affinity Purified anti-Huntingtin pS421 antibody to detect endogenous protein present in an unstimulated human PC-3 whole cell lysate (arrowhead). (Huntingtin 抗体 (pSer421))

2 images

产品编号 ABIN100604

发货至: 中国

Datasheet as PDF

抗原 See all Huntingtin (HTT) 抗体

Huntingtin (HTT)
抗原表位
15

6

4

4

4

4

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 416-424, pSer421
适用
63

45

38

6

3

2

2

1

1

1

1

1

1

1

1

1

1
人
宿主
59

21

2
兔
Compatible Secondaries
克隆类型
52

29
多克隆
标记
54

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This Huntingtin antibody is un-conjugated
应用范围
40

32

23

14

14

13

13

9

7

4

4

2

1

1
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

产品特性

Concentration Definition: by UV absorbance at 280 nm

过滤

Sterile filtered

免疫原

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 416-424 of Human huntingtin protein.

亚型

IgG

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应用备注

Anti-Huntingtin pS421 antibody has been tested for use in ELISA, immunohistochemistry and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect bands at approximately 350 kDa and 200 kDa in size corresponding to full-length Huntingtin protein and truncated (hypothetical) Huntingtin protein, respectively, by western blotting in the appropriate cell lysate or extract. This antibody is specific for the phosphorylated form of Huntingtin protein at the pS421 residue. The identity of lower molecular bands ~130 kDa is not known.

限制

仅限研究用
状态

Liquid

浓度

0.6 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C
抗原

Huntingtin (HTT)

别名

Huntington (HTT 产品)

别名

HTT antibody, hd antibody, ZHD antibody, CG9995 antibody, Dmel\\CG9995 antibody, HD antibody, Hsap\\HD antibody, Htt antibody, dHtt antibody, dhtt antibody, SLC6A4 antibody, huntington antibody, it15 antibody, htt antibody, IT15 antibody, AI256365 antibody, C430023I11Rik antibody, Hd antibody, Hdh antibody, huntingtin antibody, HTT antibody, htt antibody, LOC373520 antibody, Htt antibody

背景

Huntingtin (also known as Huntington's disease protein, Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease, a neuro-degenerative disorder characterized by loss of striatal neurons. This may be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product (see partial protein sequence below). The huntingtin gene locus is large, spanning 180 kb and consisting of 67 exons. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. Normal huntingtin protein shows a cytoplasmic localization. This protein is widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.
Synonyms: AI256365 antibody, C430023I11Rik antibody, HD antibody, HD protein antibody, HDH antibody, HTT antibody, HUNTINGTON CHOREA antibody, Huntington disease protein antibody, Huntingtin protein antibody, IT15,

基因ID

3064

UniProt

P42858

途径

PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport