Anaphase Promoting Complex Subunit 11 产品
(Anaphase Promoting Complex Subunit 11 (ANAPC11))
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Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin- protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin- conjugating E2 enzymes, it catalyzes the formation of protein- ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin- conjugating enzyme E2 to the APC/C.
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Anaphase Promoting Complex Subunit 11 抗体
High quality antibodies with extensive validation data.
Anaphase Promoting Complex Subunit 11 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Anaphase Promoting Complex Subunit 11 抗体
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Application
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- (5)
Cat. No.
ABIN1496631
Quantity
100 μL
Datasheet
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Cat. No.
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Cat. No.
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Recommended Anaphase Promoting Complex Subunit 11 蛋白
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Latest Publications for our Anaphase Promoting Complex Subunit 11 Products
: "Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15758-65, (2002) (PubMed).: "Association with cullin partners protects ROC proteins from proteasome-dependent degradation." in: Oncogene, Vol. 18, Issue 48, pp. 6758-66, (2000) (PubMed).
Synonyms and alternative names related to Anaphase Promoting Complex Subunit 11
anaphase promoting complex subunit 11 (ANAPC11), anaphase promoting complex subunit 11 L homeolog (anapc11.L), anaphase promoting complex subunit 11 (anapc11), anaphase promoting complex subunit 11 (Anapc11), anaphase-promoting complex/cyclosome 11 (APC11), anaphase promoting complex subunit 11 (APC11), anaphase-promoting complex subunit Apc11 (apc11), anaphase promoting complex subunit 11 (CAALFM_CR10610CA), ubiquitin-protein ligase Anaphase Promoting Complex (APC11), hypothetical protein (APC11), predicted protein (APC11), anaphase-promoting complex subunit 11 (LOC9320604), anaphase promoting complex subunit 11 (LOC692923), APC11 anaphase promoting complex subunit 11 homolog (yeast) (anapc11), 1110011I19Rik, anapc11, anaphase-promoting complex/cyclosome 11, APC11, Apc11p, DDBDRAFT_0187183, DDBDRAFT_0231277, DDB_0187183, DDB_0231277, F10A16.17, F10A16_17, R75218, RGD1561880, si:dkey-237i9.4, zgc:153671Protein level used designations for Anaphase Promoting Complex Subunit 11
- APC11 anaphase promoting complex subunit 11 homolog
- anaphase promoting complex subunit 11 (yeast APC11 homolog)
- anaphase-promoting complex subunit 11
- cyclosome subunit 11
- hepatocellular carcinoma-associated RING finger protein
- anaphase promoting complex subunit 11
- anaphase promoting complex subunit 11 homolog
- Apc11p
- Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
- anaphase-promoting complex subunit Apc11
- potential anaphase-promoting complex subunit Apc11
- ubiquitin-protein ligase Anaphase Promoting Complex
- hypothetical protein
- anaphase-promoting complex/cyclosome 11
- APC11
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